Meaning: The quote by Sidney Altman sheds light on the struggles and uncertainties that many graduate students face in their academic and professional pursuits. Altman, a renowned molecular biologist and Nobel laureate, reflects on a period of frustration and doubt during his time as a graduate student at Columbia University. The quote captures the essence of the challenges and uncertainties that often accompany the pursuit of a scientific career, as well as the perseverance required to overcome them.

In the quote, Altman mentions spending eighteen months as a graduate student in physics at Columbia University, during which he was waiting unhappily for an opportunity to work in a laboratory. This experience reflects a common struggle faced by many graduate students - the desire to gain practical, hands-on experience in their field of study. Laboratory work is often a crucial component of scientific research and learning, and the lack of opportunities to engage in such work can be disheartening for aspiring scientists.

Altman also expresses his uncertainty about whether he should continue in physics. This sentiment is relatable to many graduate students who grapple with the decision of whether to persist in their chosen field or consider alternative paths. The moments of doubt and introspection that Altman describes are a natural part of the academic and professional journey, and they highlight the importance of self-reflection and evaluation in navigating one's career trajectory.

The quote offers a glimpse into the personal and emotional aspects of pursuing a career in science. It underscores the challenges and internal conflicts that individuals may face along the way, highlighting the human side of scientific pursuit. Altman's candid reflection serves as a reminder that setbacks and uncertainties are part of the process, and that perseverance and resilience are essential qualities for success in the scientific world.

Sidney Altman's own journey as a graduate student in physics at Columbia University ultimately led him to make a pivotal shift to the field of molecular biology, where he made groundbreaking contributions to the understanding of RNA and was awarded the Nobel Prize in Chemistry in 1989. His career trajectory serves as a testament to the fact that periods of uncertainty and frustration can ultimately pave the way for significant achievements and discoveries.

In conclusion, Sidney Altman's quote captures the essence of the challenges and uncertainties that graduate students in the sciences often face. It reflects the internal struggles, doubts, and perseverance that are inherent in the pursuit of a career in science. Altman's own journey serves as an inspiring example of how resilience and determination can lead to remarkable accomplishments, and his candid reflection resonates with aspiring scientists who may be grappling with similar challenges in their own academic and professional pursuits.